Mark Harmon ... Superman (voice)
Alyssa Milano ... Aimee Brenner (voice)
James Woods ... Owlman (voice)
Chris Noth ... Lex Luthor (voice)
William Baldwin ... Batman (voice)
Josh Keaton ... The Flash (voice)
Gina Torres ... Super Woman (voice)
Gary Cole ... Spectre (voice)
Nolan North ... Green Lantern / Power Ring (voice)
Kari Wuhrer ... Model Citizen (voice)
John Di Maggio ... Thug (voice)
Bruce Davison ... President Slade Wilson (voice)
James Patrick Stuart ... Johnny Quick (voice)
Brian Bloom ... Ultraman (voice)
Jonathan Adams ... Martian Manhunter (voice)
Cedric Yarbrough ... Firestorm (voice)
Carlos Alazraqui ... Breakdance (voice)
Vanessa Marshall ... Wonder Woman (voice)
Jim Meskimen ... Captain Super (voice)
Bruce W. Timm ... Uncle Super (voice)
Andrea Romano ... Watchtower Computer (voice)
Richard Green ... Jimmy Olsen (voice)